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doi: 10.1016/j.pharmthera.2023.108549 9

A 17% Reduction in Overall Cancer Risk A landmark study published in JAMA Oncology (Dai H et al., August 2025), drawing on data from 14 health systems encompassing approximately 20 million patients, found that adults with obesity who were prescribed GLP-1 receptor agonists had a 17% lower risk of developing cancer compared to carefully matched non-users

The addition of GIP receptor agonism on top of dual GLP-1/glucagon activity provides synergistic metabolic effects includ

The expression of the Egr, Nos, Srf, Vegfr, Akt1, Plc, and Kras pathways in the left ovarian vein was the key for the infrarenal occlusion-induced inferior caval vein syndrome in rats [14]