15 , 16 , 17 , 18 Intriguingly, both high and low salt intake have been shown to be associated with metabolic dysfunction, leading to insulin resistance (IR), leptin resistance, obesity and metabolic syndrome
Patients with T2DM initiating GLP-1 RAs or metformin as first-line monotherapy were included (87,229 matched patients per cohort).The researchers found that compared with metformin, GLP-1 RA use was associated with a significantly lower risk for overall dementia, Alzheimer disease, and nonvascular dementias (adjusted hazard ratios, 0.90, 0.88, and 0.75, respectively)
Mitochondrial function has also emerged as a relevant topic in peptide research conversations
Hyper-stimulation of low-grade inflammatory mediators triggers peripheral endotoxemia and a persistent inflammatory state, popularly called inflammaging (reviewed in Kowalski and Mulak, 2019