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Mechanistically, GLP-1R signaling interacts with glutamatergic and gamma-aminobutyric acid (GABA)ergic pathways in mesocorticolimbic circuits, as well as with vagal afferents and hypothalamic networks that integrate energy balance and motivational states [8,12]

1 Introduction Until recently, the worldwide increase in obesity, characterized by a body mass index (BMI) exceeding 30 kg/m 2 , was widely considered an inevitable trend with limited hope for meaningful advances in pharmacological treatment

Authors were contacted if not enough data was included in the original manuscript for analysis, for clarification of terms or to confirm whether the article contained data previously published by the same research group

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