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INTRODUCTION The recent and rapid rise of the GLP-1 receptor agonists semaglutide (Ozempic, Rybelsus and Wegovy) and tirzepatide (Mounjaro and Zepbound) offers a critical lens through which we can examine the intersection of financialization, patent abuse, and health inequities in the pharmaceutical industry

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( ad ) Representative dose-response curves of cAMP assays in cells expressing human GIPR (A), human GLP-1R (B), mouse GIPR (C), or mouse GLP-1R (D)

By integrating knowledge from molecular biophysics with physiological factors, we can develop more effective strategies for injury prevention, early detection of susceptibility, and targeted rehabilitation protocols tailored to the individual needs of patients (Figure 2)