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Consequently, the development of kidney-specific antisense oligonucleotide (ASO) or adeno-associated viral (AAV) transduction methods is advantageous, as these approaches can selectively inhibit ANGPTL4 in proximal tubules, glomerular podocytes, and glomerular endothelial cells, thereby avoiding the adverse systemic effects associated with whole-body ANGPTL4 loss (Srivastava et al., 2024)

& Vital, M

We previously demonstrated that a 1-week IGF-1 LR3 infusion into fetal sheep reduces in vivo and in vitro insulin secretion suggesting an intrinsic islet defect