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This review searched literature published between 2005 and 2021 using keywords cytokines, chemokines, protein targets, small molecular metabolites, and epigenetics, and summarizes recent advances in these novel targets

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2 Adenosine signaling in the liver Caffeine is structurally similar to adenosine and is a non-selective adenosine receptor (AR) inhibitor that competently inhibits adenosine both in vitro and in vivo (van Dam et al., 2020)