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Conclusions The results of this study indicate that low-dose (0.025 mg/kg) oral rapamycin, administered three times a week for one to five months to healthy, middle-aged large breed dogs, resulted in detectable concentrations of rapamycin in four dogs that was measurable in ng/ml

Until those studies exist, subcutaneous injection remains the only route with dosing predictability

doi:10.1186/s12905-023-02225-2 8

It plays a central role in a range of important bodily functions including: Energy production - B12 is essential for converting food into usable energy at a cellular level Red blood cell formation - B12 deficiency can lead to a type of anaemia that causes fatigue and weakness Nervous system function - B12 supports the myelin sheath that protects nerve fibres, making it important for neurological health Mood regulation - B12 is involved in the production of serotonin and dopamine, the neurotransmitters that regulate mood Cognitive function - adequate B12 levels support concentration, memory, and mental clarity Immune function - B12 plays a role in the production and activity of immune cells When B12 levels fall below optimal, these functions are affected often in ways that are subtle enough to go unnoticed or be attributed to other causes for a long time before the deficiency is identified