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Compared to males, females also had substantially lower expression levels for the rate-limiting enzyme in glutathione synthesis, Gclc , under both basal and statin-treated conditions, but neither sex experienced a reduction in response to statin (Fig
While GLP-1RAs demonstrate immunomodulatory potential relevant to SS pathogenesis through their effects on key immune cell populations, direct experimental evidence characterizing their impact on SS-specific immune dysregulation remains strikingly limited
Adiponectin mediates these effects by promoting the storage of triglyceride (TG) in white adipose tissue through stimulation of lipoprotein lipase and by increasing muscle fat oxidation and glucose uptake by stimulation of 5 adenosine monophosphate-activated protein kinase (AMPK) in muscle (Figure 3) [40]
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