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Effect of IMCIVREE on Hunger in Patients with Obesity due to POMC, PCSK1, or LEPR Deficiency In Trials 3 and 4, patients 12 years and older self-reported their daily maximal hunger in a diary, assessed by the Daily Hunger Questionnaire Item 2

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In a model of SAMe depletion achieved via folate deprivation, subsequent SAMe supplementation restored acetylcholine concentrations and cognitive performance to levels seen in the presence of folate, and reduced aggressive behavior (17)

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