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DSIP unterscheidet sich von klassischen Schlafmitteln fundamental: Es ist ein endogenes, krpereigenes Peptid ohne Sedationswirkung, ohne Toleranzentwicklung und ohne Suchtgefahr

Despite advances in phenotypic and mechanistic characterization of three distinct permeability pathways, development of experimental agents that specifically target these pathways, and remarkable efficacy in preclinical models, pathway-targeted therapies have not been tested in human subjects

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