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However, there are many unusual symptoms associated with vitamin B12 deficiency, and most will disappear after taking vitamin B12 long enough to get the stores up to a normal amount and have maintained stable levels of vitamin B12

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337 Concurrently, age-related decreases in PINK1/Parkin-mediated mitophagy promote oxidative stress and mitochondrial dysfunction, which can trigger synovial inflammation and reduce the osteoclast activity critical for healthy bone remodeling, thereby contributing to joint damage and motor impairment

Science objectives [edit] The Juice orbiter will perform detailed investigations on Ganymede and evaluate its potential to support life