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Individuals without GSTM1 may have a greater risk of malignant transformation in endometriotic lesions due to insufficient elimination of oxidative stress products ( 2.4 Abnormal gene methylation Epigenetic modifications, including DNA methylation, histone modifications, and noncoding microRNAs, have emerged as noteworthy factors in the development of EAOC ( On the other hand, the anomalous hypomethylation of the promoter regions of long interspersed element-1 (LINE-1) ( The tumor suppressor gene RASSF2, which has been recently identified, exerts a notable influence on the Ras signaling pathways

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