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doi: 10.1016/s0008-6363(01)00313-3

Since metformin can be used off-label for PCOS , it might be a beneficial alternative to Ozempic if you also have a PCOS diagnosis

The trapping mechanism implies that a blocker can enter the open ion channel followed by gate closure behind the blocker, thereby trapping it inside the ion channel pore until the channel is opened again