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Surface-state emission, in contrast, originates from trap sites or heteroatom dopants that introduce mid-gap states, generating emission highly sensitive to pH, solvent polarity, and oxidation level [Figure 1BII)

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The process can cause alterations in biological membranes and the formation of substances harmful to the body that can form aggregates with proteins and nucleic acids

for example, hawthorn leaf flavonoids have been shown to exert neuroprotective effects in an AD model by activating the Nrf2/ARE pathway, enhancing antioxidant enzyme activities, and reducing oxidative stress and neuroinflammation (Xu et al., 2023)