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Choline deficiency causes hepatic steatosis (fatty liver disease) and leads to loss of muscle membrane integrity

CXCL9, CXCL10, CXCL11, and their receptor (CXCR3) in neuroinflammation and neurodegeneration

This is the rate-limiting step of GSH biosynthesis

Key findings include: Upregulation of Shh pathway components in ischemic brain regions Enhanced neural stem cell proliferation and differentiation Improved angiogenesis supporting tissue repair Modulation of blood-brain barrier integrity The Shh pathway activation appears particularly relevant in stroke recovery models, where enhanced neurogenesis and vascular support correlate with functional improvements