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In Vitro and Ex Vivo Evidence (Moderate-Strong) The strongest mechanistic data comes from cell culture and organ culture studies

The body continues to benefit from residual improvements during the off-cycle

Older adults are at a higher risk for B12 deficiency for a number of reasons: Digestive issues that interfere with absorption Reduced food intake Dental issues that discourage meat consumption Disturbances to the gut biome Excess alcohol consumption Reduced stomach acid production that lowers absorption Reduced consumption and absorption of B12 can lead to neurological disorders, cognitive impairment and a number of other issues that accelerate aging and reduce overall quality of life

Changes in gut and plasma microbiome following exercise challenge in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)