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No one in the GLP-1 group experienced significant gastrointestinal adverse events during the study, and none discontinued GLP-1 use

There, they are broken down through oxidation and converted to energy for all tissues, including the heart, liver, and skeletal muscles

Characteristic alterations in gut microbial composition in DKD include a marked reduction in short-chain fatty acid (SCFA)-producing bacteriaparticularly butyrate-producing members of the Lachnospiraceae family and genera such as Blautia and Faecalibacteriumalongside an overgrowth of potentially pathogenic taxa, including Enterobacteriaceae and other gamma-proteobacteria (86)