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It also breaks down muscle for energy, especially when: Protein intake is insufficient Resistance training stimulus is absent Weight loss is too rapid Caloric deficit is too aggressive The Protein Paradox Here's where many GLP-1 users get stuck: you need more protein during weight loss, but GLP-1s make it harder to eat protein
In the SURMOUNT 1 trial, tirzepatide at doses of 5 mg, 10 mg and 15 mg were evaluated against placebo, with pooled tirzepatide groups resulting in significant decreases in total cholesterol, LDL-C, VLDL-C, FFA, and triglycerides and an increase in HDL-C at week 72 of follow-up [35]
Clinical guidelines recommend 0.8-1.0g protein per pound of goal body weight to preserve muscle mass during rapid weight loss
What was once a relatively contained therapeutic class within endocrinology has expanded into a dual-purpose platform that operates across two distinct clinical domains
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