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It stimulates angiogenesis via the VEGF-eNOS-NO pathway, accelerates fibroblast migration, and promotes type I collagen synthesis

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Kidney function biomarkers, including creatinine clearance and urea levels, shift towards younger reference values, indicating the restoration of tissue homeostasis

Cagrilintide Starting Dose and Titration Unlike tirzepatide's gradual multi-step escalation, cagrilintide trials have typically employed a simpler titration approach: Typical Cagrilintide Escalation: Weeks 1-4: 0.6 mg weekly Weeks 5-8: 1.2 mg weekly Week 9 onward: 2.4 mg weekly (maintenance) This three-step approach allows for tolerance development while reaching the therapeutic dose more quickly than tirzepatide's six-step protocol