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(2014) 'Induction of genomic DNA hypomethylation in the offspring of rats consuming diets mildly deficient in vitamin B2, B6, B12 and folate', *Nutrition*, 30(8), pp

Ein derart niedriger Quotient zeigt, dass der grte Anteil des vorhandenen Glutathions bereits oxidiert sind

Often creates active metabolites Phase II metabolism: Conjugation, glucuronidation, acetylation etc Occurs in the liver and kidneys Involves other enzymes to CYP450 (various transferases) Often involves the addition of polar groups Often deactivates metabolites Excretion This involves the removal of the drug from the body

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