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Glucagon-like peptide-1 (GLP-1) is a hormone naturally produced in your gut in response to food, especially carbohydrates and sugars

Since an interaction between the host and phage had already been identified in the earlier AG screen, infections were not restriction to a single phage replication cycle, but allowed to proceed further to achieve full depletion of the phage-sensitive Tn5-knockout mutants in the pool

These food factors improve the breakdown of glucose and increase the secretion of GLP-1

The rate of loss accelerates during the dose escalation phase and typically peaks around weeks 16-32 when you reach higher maintenance doses