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Common causes and risk factors include: Straining during bowel movements : Often a result of constipation or diarrhea

This review integrates findings from preclinical and clinical studies to examine how GLP-1RAs alter gut microbial composition and how microbial metabolites shape hormone secretion, immune balance, gutbrain communication, and tissue-specific metabolic responses

The market has been expanding at roughly 9 percent annually since 2015.4 Much of that growth is driven by GLP-1 receptor agonists like semaglutide, but the next wave may include performance- and recovery-oriented peptides designed for active and aging populations