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Recognizing these translational gaps is essential for the development of more predictive preclinical systems, such as humanized mouse models and integrated organoidimmune coculture platforms, which may bridge the gap between experimental efficacy and real-world applicability
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Further patient characteristics have been described and categorized by prednisolone medication in Supplementary Table S3, by periodontal status in Supplementary Table S4, and CAL in Supplementary Table S5
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