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A sufficient supply of B vitamins, including B12, is truly important for converting the food we eat into usable energy

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Li W, Quigley L, Yao DL, Hudson LD, Brenner M, Zhang BJ, Brocke S, McFarland H, Webster HD (1998) Chronic relapsing experimental autoimmune encephalomyelitis: effects of insulin-like growth factor-I treatment on clinical deficits, lesion severity, glial responses, and blood brain barrier defects

This finding is consistent with the broader observation that GHS-R1a receptors are expressed in multiple tissues beyond the pituitary, including kidney, heart, and immune cells, suggesting pleiotropic protective functions