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"Way back, when there really weren't too many other agents for obesity treatment," she'd prescribe more of it, she told Insider, but that was largely because "there wasn't anything else." But metformin's effects on weight loss are "kind of mild," compared to newer drugs like semaglutide, Apovian said, and persistent side effects like stomach cramps and diarrhea are a common concern among patients taking metformin

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Canada Research has demonstrated that Tesamorelin, in particular, targets visceral fat reduction, while Ipamorelin and CJC-1295 No DAC enhance lipolysis