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Sustained Weight Maintenance: The SCALE Maintenance trial demonstrated that 81.4% of Liraglutide-treated patients maintained their initial 5% weight loss, compared to only 48.9% of placebo-treated patients , proving its effectiveness for long-term weight management rather than just initial loss

This bifurcation Akt/mTORC1 for protein synthesis, ERK1/2 for proliferation represents the canonical dual anabolic output of IGF-1R activation, and both arms are relevant to skeletal muscle research depending on the biological question (hypertrophy vs regeneration)

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