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Repatha (evolocumab) targets a protein called PCSK9, which binds to LDL receptors on liver cells and destroys them

In Zepbound clinical trials, hair thinning was reported in 45% of users overall but in 7.1% of women versus less than 1% of men

Preclinical studies completed to date have shown that AMX0114 achieves potent, dose-dependent, and durable knockdown of CAPN2 mRNA expression and calpain-2 protein levels in human motor neurons