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* Correspondence: Rajarsi Mandal, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Conclusion The comparison of tirzepatide vs semaglutide for metabolic research is not a question of which compound is universally superior it is a question of which compound best serves the specific research endpoint under investigation

Both medications commonly cause mild gastrointestinal effects such as nausea, reduced appetite, and occasional vomiting during dose escalation, typically diminishing over weeks

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