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Richard Russell Wenwen Wang, 1, * Aihua Mei, 1, * Hang Qian, 1, * Dongfeng Li, 1 Hao Xu, 1 Jishun Chen, 1 Handong Yang, 1 Xinwen Min, 1 Chunlei Li, 1 Li Cheng, 1 Jun Chen 1, 2 1 Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Hubei Key Laboratory of Wudang Local Chinese Medicine Research (Hubei University of Medicine), Shiyan, Peoples Republic of China
This graduated approach is designed to improve gastrointestinal tolerability, but it also allows the body time to adapt metabolically
The fed group experienced significantly lower systemic semaglutide exposure after the 10th dose, whereas both the fasting and reference groups achieved therapeutic concentrations [26]