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The medication's mechanism of delaying gastric emptying and its common gastrointestinal adverse effects (nausea, vomiting, diarrhoea, constipation, and abdominal pain) may potentially exacerbate symptoms in patients with active or even quiescent Crohn's disease

57,59 Exenatide, a synthetic peptide with 50% sequence homology to GLP-1, is resistant to dipeptidyl peptidase-4-mediated degradation 54 and was the first GLP-1RAs approved by the US Food and Drug Administration (FDA) for T2DM treatment in 2005

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