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Glucose-Lowering Therapy for People With Cardiovascular Disease or Risk Factors for Cardiovascular Disease For people with type 2 diabetes and established ASCVD or indicators of high ASCVD risk, HF, or CKD, an SGLT2 inhibitor and/or GLP-1 RA with demonstrated cardiovascular benefit ( Table 9.2 ) is recommended independent of A1C, with or without metformin use, and in consideration of person-specific factors ( Fig