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Zepbound mimics the natural hormones, GLP-1 and GIP, that are crucial in controlling appetite and consumption

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However, observed barrier defects and associated diarrhea even in these mice did not result in changes in claudin-1, -2, -3, and -4 expression and cellular distributions, but rather correlated with the rearrangement of cellular distribution of occludin, and to some extent with JAM proteins

The most common side effects are gastrointestinal symptoms such as nausea, diarrhoea, and vomiting, though some individual patients do report taste disturbances