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It has become a prominent subject of scientific research due to its potential role in tissue repair, cellular regeneration, angiogenesis, and recovery-related pathways

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The folate-cobalamin interaction is pivotal for normal synthesis of purines and pyrimidines and the transfer of the methyl group to cobalamin is essential for the adequate supply of tetrahydrofolate, the substrate for metabolic steps that require folate

However, more research is highly required from both observational and experimental studies to investigate the role of chronic PE training in vitiligo disease on four spheres: (i) disease prevention