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Notably, administration of GEP44 resulted in an 80% reduction in food intake and a more profound loss of body weight than what could be achieved in response to treatment with several of the US Food and Drug Administration (FDA)-approved GLP-1RAs, including Ex-4 and liraglutide (LIRA)

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The REDEFINE 1 trial used a co-administered single-injection product, which is not the same as either of these patterns

Gastrointestinal tolerability of once-weekly GLP-1 receptor agonists: a systematic review