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T-cell responses, evaluated through intracellular cytokine staining, indicate that 93.3% (14/15) of assessable patients exhibit SARS-CoV-2-specific T-cell responses following the initial dose, comprising CD 4+ responses in 80% and CD 8+ responses in 60%, with 80% demonstrating polyfunctional responses involving TNF-, IFN-, and IL-2

The effects of DSIP appear to persist beyond the single night of administration for some individuals, potentially allowing less frequent dosing while maintaining benefits

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 40% by weight of the poloxamer