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COP1 dimerizes through its coiled-coil domain, allowing another COP1 (COP1 WD40a ), which further interacts with a separate DDD-E2 complex in a similar manner, to associate with blades V-VI of DET1 (Fig

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By comparing both analyses, we can distinguish general prescribing trends from those specific to adolescents with obesity, helping to contextualize the extent to which these medications are used in alignment with clinical guidelines

In the second, more recent study, a case report from our lab (Parimbelli et al., 2021) showed that a high intensity/low duration training program of 6 months was safe and effective in improving body metabolism and aerobic fitness in a 14-year-old CPTII-deficiency girl