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Moreover, microbial metabolites such as short-chain fatty acids and secondary bile acids influence thyroid hormone metabolism by regulating hepatic deiodinase activity, enterohepatic circulation, and tissue sensitivity to T 3 (Miquel et al., 2013

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The addition of metabolic biomarkers improved the predictive ability of models using IMPACT and CRASH parameters to estimate severity/prognosis [18, 30, 31]