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The name sounds complicated, but how they work is surprisingly straightforward

Hypoglycemia: While GLP-1 medications themselves rarely cause hypoglycemia (low blood sugar) when used as monotherapy, combining them with a mechanism of action that causes hypoglycemia such as insulin or sulfonylureas can increase the risk of hypoglycemia

During the perimenopausal and postmenopausal periods, declining oestrogen levels are associated with increased central adiposity, insulin resistance, and a higher risk of metabolic syndrome

Baggio LL, Yusta B, Mulvihill EE, Cao X, Streutker CJ, Butany J, Cappola TP, Margulies KB, Drucker DJ