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120 The binding of an IGF1 receptor ligand results in the autophosphorylation and subsequent phosphorylation of either IRS-1 (Insulin Receptor Substrate-1) or IRS-2 (Insulin Receptor Substrate-2)

Preclinical studies have clearly demonstrated that GLP-1RAs effectively reduce hepatic macrophage infiltration and suppress expression of TNF- , IL-6, and other pro-inflammatory mediators in animal models of MASLD (21, 22)

Studies found that PT-141 works for both males and females