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Contraindicated in patients with certain types of anemia (such as folate-deficiency anemia) where B12 supplementation may not be appropriate

Long-term deficiency can damage the protective myelin around nerves, and if it is not addressed, some of that damage can become permanent, causing numbness, pain, and balance problems

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Some competitive athletes use it to target final stubborn areas during cutting phases, and there's anecdotal support for this but the dramatic results seen in higher-body-fat research subjects won't replicate at 12% BF