The entire body composition evidence base comes from preclinical mouse studies and cell culture experiments
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Scieglinska, D., Piglowski, W., Chekan, M., Mazurek, A
Extra fat cells act like mini chemical factories, releasing hormones and inflammatory messengers called cytokines, such as interleukin-6 (IL-6), Tumor necrosis factor alpha (TNF-alpha), interleukin-17 (IL-17), and others