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Cell Metab (2023) 35(1):3655

Preclinical studies in accelerated mouse models of diet-induced steatohepatitis have demonstrated that retatrutide improves steatohepatitis through mechanisms involving enhanced hepatic fat oxidation, reduced lipogenesis, decreased inflammation, and attenuation of fibrosis markers, supporting the rationale for clinical development in MASH [33]

The present review article focuses on summarizing the physiological role of seleno-GPxs and their synthetic mimics (mainly organoselenium compounds) in the radiation response of preclinical model systems

Preclinical research suggests they reduce cholesterol saturation in bile and inhibit the first stage of cholesterol crystal formation (Song 2015