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The liraglutide PK for the L-0.9 mg 1-10 was modeled using the half-life of absorption from the SC space (t 1/2, SC 0.16 h) and the known half-life of elimination from systemic circulation in rats (t 1/2, serum 0.167 days) (Table S1) ( 58 )

The difference is that the gatekeeper is the clinicians judgment and clinical process, not the insurers utilization rules

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others include ETASU (Elements to Assure Safe Use) requiring prescriber certification, patient enrollment in registries, and dispensing only through certified pharmacies