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Another trial ( n = 30) using the same dosing and duration reported a similar benefit, with an estimated treatment difference of 7.8 kg ( 7.7% in body weight) in favor of semaglutide [168]

modest improvements in LDL and HDL ratios Liver health: Significant improvements in non-alcoholic fatty liver disease (NAFLD), an increasingly common obesity-related condition Sleep apnea: The SURMOUNT-OSA trial showed tirzepatide reduced sleep apnea severity by up to 63% Joint health: Weight reduction directly reduces mechanical load on hips, knees, and ankles reducing pain and improving mobility Ready to Find Out If GLP-1 Medication Is Right for You

Although both medications contain semaglutide, the doses are not directly equivalent as one form is taken daily and the other weekly

Notably, TD leads to disturbed expression of junction protein subtypes in Ctenopharyngodon idella (181)