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The strength of the TRIUMPH-1 data 28.3% weight loss at 80 weeks, 45.3% achieving bariatric-surgery-level outcomes gives Eli Lilly a compelling submission package

The polyethylene glycolylated mouse leptin antagonist (PEG-MLA)-treated mice exhibit increased fasting and glucose stimulated plasma insulin levels, decreased whole-body insulin sensitivity, elevated hepatic glucose production, and impaired insulin-mediated suppression of hepatic glucose production (Levi et al., 2011)