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Simultaneously, GLP-1 suppresses glucagon secretion from alpha cells, further contributing to improved glycaemic control

Subsequent studies confirmed senolytic activity in additional cell types including chondrocytes, Leydig cells, keloid fibroblasts, and endothelial cells demonstrating that the FOXO4-p53 dependency is a conserved feature across multiple senescent cell populations

Absorption, Timing, and Practical Considerations for Oral Tablets Oral GLP-1 tablets require specific timing to maximize absorption: take them on an empty stomach with 48 ounces of water, at least 30 minutes before food or other medications

Under standard review timelines, that places potential FDA approval somewhere around mid to late next year