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Dietary Changes: Consuming foods rich in vitamin B12, such as lean meats, eggs, dairy products, and fortified cereals, can help supplement the body's requirements

For individuals in the UK seeking support with weight management today, options recommended within the NHS framework include: Lifestyle interventions as first-line management, supported through Tier 2 community weight management services Orlistat for eligible patients, available via GP prescription Semaglutide (Wegovy) MHRA-licensed for chronic weight management and recommended by NICE (TA875) for use within specialist Tier 3 weight management services for qualifying patients, subject to eligibility criteria including BMI thresholds and weight-related comorbidities

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Participants were randomized 1:1:1 to retatrutide 9 mg weekly, retatrutide 12 mg weekly, or placebo, and treated for 68 weeks