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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

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Adipose tissue, particularly visceral fat, produces elevated levels of pro-inflammatory cytokines including IL-6, TNF-alpha, and thymic stromal lymphopoietin (TSLP), all of which drive the type 2 inflammatory response underlying atopic dermatitis