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When to Stop Discontinue ipamorelin immediately if ALT or AST rises more than 3 times the upper limit of normal from baseline, if fasting glucose exceeds 200 mg/dL on two consecutive measurements, if new-onset ascites or worsening encephalopathy appears within 8 weeks of initiation, or if the patient develops fluid retention unresponsive to dietary sodium restriction

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These studies suggest that MTHFR 677 polymorphism can result in elevated homocysteine levels, which may lead to an increased risk of thrombotic events

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