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The implementation of a combination of biomarker tests, that includes imaging measures of BBB dysfunction, could aid in early diagnosis, in monitoring disease progression and in evaluating treatment response to new drugs (Vellas, 2021)

Quantitative analysis of cochlear structures in the house mouse in relation to mechanisms of acoustical information processing

Although glutamate is the major downstream product of glutamine, glutamate supplementation during glutamine deprivation cannot rescue the impaired cell growth or mitochondrial respiration 16,43,44,45 , indicating that mitochondrial GLS-catalyzed cleavage of the gamma-nitrogen of glutamine is essential for glutaminolysis

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